Belgrade has a reputation for offering a vibrant nightlife, and many clubs that are open until dawn can be found throughout the city. The most recognizable nightlife features of Belgrade are the barges (splavovi) spread along the banks of the Sava and Danube Rivers.

Many weekend visitors—particularly from Bosnia-Herzegovina, Croatia and Slovenia—prefer Belgrade nightlife to that of their own capitals, due to a perceived friendly atmosphere, great clubs and bars, cheap drinks, the lack of language difficulties, and the lack of restrictive night life regulation.

Famous alternative clubs include Akademija and the famed KST (Klub Studenata Tehnike) located in the basement of the University of Belgrade's Faculty of Electrical Engineering. One of the most famous sites for alternative cultural happenings in the city is the SKC (Student Cultural Centre), located right across from Belgrade's highrise landmark, the Beogradanka. Concerts featuring famous local and foreign bands are often held at the centre. SKC is also the site of various art exhibitions, as well as public debates and discussions.

A more traditional Serbian nightlife experience, accompanied by traditional music known as Starogradska (roughly translated as Old Town Music), typical of northern Serbia's urban environments, is most prominent in Skadarlija, the city's old bohemian neighbourhood where the poets and artists of Belgrade gathered in the nineteenth century and early twentieth century.

Skadar Street (the centre of Skadarlija) and the surrounding neighbourhood are lined with some of Belgrade's best and oldest traditional restaurants (called kafanas in Serbian), which date back to that period. At one end of the neighborhood stands Belgrade's oldest beer brewery, founded in the first half of the nineteenth century. One of the city's oldest kafanas is the Znak pitanja.

The respected Times newspaper in the UK reported that Europe's best nightlife can be found in buzzing Belgrade.